abstract：:Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the intestinal tract. Baicalin, originally isolated from the root of the Chinese herb Huangqin (Scutellaria baicalensis Georgi) and its main active ingredient, has a protective effect against inflammatory responses in several diseases. The presen...

journal_title：International immunopharmacology

authors： Zhu W,Jin Z,Yu J,Liang J,Yang Q,Li F,Shi X,Zhu X,Zhang X

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Iguratimod (T-614) has been confirmed as a highly efficacious and safe novel disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis therapy in China and Japan due to its potent anti-inflammation effect. Here, we investigate the effects of Iguratimod on osteoclast differentiation, migration ...

journal_title：International immunopharmacology

authors： Gan K,Yang L,Xu L,Feng X,Zhang Q,Wang F,Tan W,Zhang M

更新日期：2016-06-01 00:00:00

abstract：:Previous studies have demonstrated that polypeptides extracted from scorpion venom (PESV) inhibited cell proliferation in several tumors, however, the effect on dysfunctional and exhausted natural killer cells which contribute to tumor escape from immune surveillance remain to be elucidated. In this study, we determin...

journal_title：International immunopharmacology

authors： Chen H,Zhidan W,Xia R,Zhaoxia W,Qing J,Qiang G,Haipeng Y,Hengxiao W

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:The precision-cut kidney slice (PCKS) model appears to be a useful ex vivo model of renal fibrosis. However, little in-depth molecular investigation on the PCKS model has been performed. Therefore, the aim of this study will be to investigate and validate the molecular validity of this model. METHODS:The PC...

journal_title：International immunopharmacology

authors： Zhang S,Liu Q,Xiao J,Lei J,Liu Y,Xu H,Hong Z

更新日期：2016-05-01 00:00:00

abstract：:Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident popula...

journal_title：International immunopharmacology

authors： Chen K,Wang JM,Yuan R,Yi X,Li L,Gong W,Yang T,Li L,Su S

更新日期：2016-05-01 00:00:00

abstract：:High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play important roles in the development of sepsis-induced acute lung injury (ALI). Ketamine is considered to confer protective effects on ALI during sepsis. In this study, we investigated the effects of ketamine on HMG...

journal_title：International immunopharmacology

authors： Li K,Yang J,Han X

更新日期：2016-05-01 00:00:00

abstract：:Recent studies showed that Madecassoside (MAD), a pentacyclic triterpene isolated from Centella asitica (L.), was used as a therapeutic agent in wound healing and also as an anti-inflammatory, anti-oxidative activities and anti-aging agent. However, its role in cancer has not been elucidated. In our present study, hep...

journal_title：International immunopharmacology

authors： Li Z,You K,Li J,Wang Y,Xu H,Gao B,Wang J

更新日期：2016-04-01 00:00:00

abstract：:1.We investigated the role of Annexin (ANX)-A1 and its receptor, ALX/FPR2, in the regulation of mast cell degranulation produced by compound 48/80. 2.Both human cord-blood derived mast cells (CBDMCs) and murine bone marrow derived mast cells (BMDMCs) release phosphorylated ANX-A1 during treatment with glucocorticoids ...

journal_title：International immunopharmacology

authors： Sinniah A,Yazid S,Perretti M,Solito E,Flower RJ

更新日期：2016-03-01 00:00:00

abstract：:Isoliquiritigenin (isoLQ), a chalcone found in licorice, has shown a variety of biological activity including anti-inflammatory and antioxidative effects, and the distribution of isoLQ in gastrointestinal tract was higher than any other tissues. Thus, we evaluated whether or not isoLQ attenuated the dextran sulfate so...

journal_title：International immunopharmacology

authors： Choi YH,Bae JK,Chae HS,Choi YO,Nhoek P,Choi JS,Chin YW

更新日期：2016-02-01 00:00:00

abstract：:Tuberculosis (TB) remains as a global health problem. The prevalence of this infection is related to the association with other diseases, such as HIV, neglect treatment and misuse of antibiotics. Hence, the identification of new drugs is required to eradicate TB. Possible alternatives to existing antibiotics include p...

journal_title：International immunopharmacology

authors： Guzmán-Beltrán S,Rubio-Badillo MÁ,Juárez E,Hernández-Sánchez F,Torres M

更新日期：2016-02-01 00:00:00

abstract：:Immune regulation in response to recombinant cytokines (Th1- and Th2-types) is poorly understood in fish. Therefore, we synthesized and purified the Japanese pufferfish, (Takifugu rubripes) recombinant cytokines, namely interferon-gamma (IFN-γ), IFN-γrel, interleukin (IL)-4/13A and IL-4/13B, and then administered by i...

journal_title：International immunopharmacology

authors： Biswas G,Nagamine R,Hikima J,Sakai M,Kono T

更新日期：2016-02-01 00:00:00

abstract：:The immunomodulatory properties of mannose-binding lectins ConBr (Canavalia brasiliensis) and CFL (Cratylia argentea) were investigated comparatively in a model of Salmonella infection. The lectins were intraperitoneally (i.p.) administered to mice daily for three days before the bacterial challenge with Salmonella en...

journal_title：International immunopharmacology

authors： Silva AF,Matos MP,Ralph MT,Silva DL,de Alencar NM,Ramos MV,Lima-Filho JV

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic inflammatory/autoimmune mediated diseases. Experimental models of arthritis and clinical indications have highlighted an...

journal_title：International immunopharmacology

authors： Zaky DS,El-Nahrery EM

更新日期：2016-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) envelope E2 is a glycoprotein that are implicated in HCV infection by facilitating its entry and immune evasion, which in turn leads to hepatitis, hepatocellular carcinoma and other chronic liver diseases. It is reported that the HCV E2 stem region comprise a functional region for HCV entry; ho...

journal_title：International immunopharmacology

authors： Liu X,Chen N,Lin S,Liu M

更新日期：2016-01-01 00:00:00

abstract：:Lung cancer is the major cause of cancer-related mortality and is a growing economic burden worldwide. Chemoprevention has emerged as a very effective preventive measure against carcinogenesis and several bioactive compounds in diet have shown their cancer curative potential on lung cancer. Naringenin (NRG), a predomi...

journal_title：International immunopharmacology

authors： Bodduluru LN,Kasala ER,Madhana RM,Barua CC,Hussain MI,Haloi P,Borah P

更新日期：2016-01-01 00:00:00

abstract：:Endotoxin can stimulate inflammatory cytokine release from monocytes/macrophages and result in septic shock. Glycyrrhetinic acid (GA), the main bioactive component of licorice, possesses substantial anti-inflammatory activity. Here, we explored effect of 11-deoxy-18α-glycyrrhetinic acid-30-ethyl ester (DGAEE), a newly...

journal_title：International immunopharmacology

authors： Luo J,Liu M,Wu X,Dou Y,Xia Y,Dai Y,Wei Z

更新日期：2015-12-01 00:00:00

abstract：:Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects. The objective of the study is to investigate the effects of melatonin in hepatic ischemia/reperfusion (I/R) induced lung injury and explore its underlying mechanisms. Hepatic I/R injury was induced via portal vein and h...

journal_title：International immunopharmacology

authors： Zhou L,Zhao D,An H,Zhang H,Jiang C,Yang B

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was performed to evaluate the efficacy of ulinastatin (UTI) and thymosin α1 (Tα1) based immunomodulatory strategy in sepsis patients. METHODS:A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of sepsis with t...

journal_title：International immunopharmacology

authors： Han D,Shang W,Wang G,Sun L,Zhang Y,Wen H,Xu L

更新日期：2015-12-01 00:00:00

abstract：:We report the case of an HIV-1 positive patient with primary demyelinating neuropathy (Guillain-Barré syndrome); after intravenous immunoglobulin treatment (IVIG), he presented with an increase in CD4 and CD8 cell counts and a decrease in plasma viral load. Currently, there is little reported research regarding IVIG t...

journal_title：International immunopharmacology

authors： Rosca EC,Rosca O,Simu M

更新日期：2015-12-01 00:00:00

abstract：:The confluent pulmonary endothelium plays an important role as a semi-permeable barrier between the vascular space of blood vessels and the underlying tissues, and it contributes to the maintenance of circulatory fluid homeostasis. Pulmonary endothelial barrier dysfunction is a pivotal early step in the development of...

journal_title：International immunopharmacology

authors： Liu H,Yu X,Yu S,Kou J

更新日期：2015-12-01 00:00:00

abstract：:Mastitis is a postpartum disease in both humans and animals. Staphylococcus aureus (S. aureus) can induce mastitis by infection of the lactiferous ducts. There is no efficacious treatment for S. aureus-induced mastitis. Betulin has been confirmed to have multiple biological activities, including anti-inflammatory prop...

journal_title：International immunopharmacology

authors： Guo MY,Li WY,Zhang Z,Qiu C,Li C,Deng G

更新日期：2015-12-01 00:00:00

abstract：:In a preliminary experiment, it was found that oleanolic acid (OA), which is widely distributed in food and medicinal plants, inhibited interleukin (IL)-6/tumor growth factor beta-induced differentiation of splenic T cells into Th17 cells. Moreover, OA induced the differentiation of splenic T cells into Treg cells. Th...

journal_title：International immunopharmacology

authors： Kang GD,Lim S,Kim DH

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The pregnant uterine microenvironment is repleted with Toll-like receptors (TLRs), however, their roles of these receptors in establishing tolerance to growing fetus are largely unknown. RESULT:Decidual TLR1, TLR3, TLR4, TLR8 and TLR9 gene expressions were significantly over-expressed in patients of spontan...

journal_title：International immunopharmacology

authors： Kang X,Zhang X,Liu Z,Xu H,Wang T,He L,Zhao A

更新日期：2015-12-01 00:00:00

abstract：:Acteoside has anti-inflammatory and antioxidant potentials. Nevertheless, little information is available about the pharmacological mechanism of acteoside. Here, we report the regulatory effects and underlying mechanisms of acteoside on interleukin (IL)-32-induced inflammatory reactions using human monocytes cells lin...

journal_title：International immunopharmacology

authors： Nam SY,Kim HM,Jeong HJ

更新日期：2015-12-01 00:00:00

abstract：:Anti-nicotine vaccines comprise nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). Unfortunately, those tested clinically have failed to improve overall long term quit rates. We had shown in mice that carrier, hapten, linker, hapten load (number of haptens per carrier molecule), aggregation and ad...

journal_title：International immunopharmacology

authors： McCluskie MJ,Thorn J,Gervais DP,Stead DR,Zhang N,Benoit M,Cartier J,Kim IJ,Bhattacharya K,Finneman JI,Merson JR,Davis HL

更新日期：2015-12-01 00:00:00

abstract：:The potentiation of the immune system in pregnant rats was performed with Complete Freund's Adjuvant [CFA; 20μl, subcutaneous at gestation day (GD) 18] in experimentally-induced hyperthyroidism by Levo-thyroxine (L-T4; 10μg/100g of b.w., intraperitoneal from GD 2 to 17). The potential effects on the fetal neuroendocri...

journal_title：International immunopharmacology

authors： Ahmed RG,Abdel-Latif M,Mahdi EA,El-Nesr KA

更新日期：2015-12-01 00:00:00

abstract：:Butyrylcholinesterase (BChE) degrades acetylcholine in addition to acetylcholinesterase (AChE) which is involved in embryonic development of limbs. Since BChE is expressed by osteoblast-like cells we asked whether it is functional in adult bone remodeling. We addressed this issue by analyzing BChE gene-deficient mice ...

journal_title：International immunopharmacology

authors： Haupt M,Kauschke V,Sender J,Kampschulte M,Kovtun A,Dürselen L,Heiss C,Lips KS

更新日期：2015-11-01 00:00:00

abstract：:Corneal epithelial erosion is one of the most common problems in clinical ophthalmology. Despite significant progress in understanding how the cornea heals, clinically available pharmacological therapies that can promote repair and prevent visual complications remain limited. We have recently demonstrated that the ace...

journal_title：International immunopharmacology

authors： Chernyavsky AI,Galitovskiy V,Grando SA

更新日期：2015-11-01 00:00:00

abstract：:The cholinergic anti-inflammatory pathway spans several macro- and micro-environments to control inflammation via α7 nicotinic acetylcholine receptors (nAChRs). Physiologic inflammation is necessary for normal wound repair and is triggered, in part, via Toll-like receptors (TLRs). Here, we demonstrate that keratinocyt...

journal_title：International immunopharmacology

authors： Kishibe M,Griffin TM,Radek KA

更新日期：2015-11-01 00:00:00

abstract：:It has been several years since the function of the non-neuronal cholinergic system was independently reported in cardiomyocytes by several research groups. Although these findings initially seemed to be negligible and insignificant, extraordinary findings about cardiomyocytes were subsequently reported in studies inv...

journal_title：International immunopharmacology

authors： Kakinuma Y

更新日期：2015-11-01 00:00:00

abstract：:Acetylcholine (ACh), a classical neurotransmitter, has been shown to be present in various non-neuronal cells, including cells of the eye, such as corneal epithelium and endothelium, and to have widespread physiological effects such as cytoskeleton reorganization, cellular proliferation, differentiation, and apoptosis...

journal_title：International immunopharmacology

authors： Słoniecka M,Backman LJ,Danielson P

更新日期：2015-11-01 00:00:00

abstract：:A novel nicotinic acetylcholine (ACh) receptor (nAChR)-mediated transduction pathway, regulating keratinocyte function, has been elucidated in studies of secreted mammalian Ly6/urokinase plasminogen activator receptor-related protein (SLURP)-1 and -2. SLURPs are members of Ly6/neurotoxin superfamily (Ly6SF) of protein...

journal_title：International immunopharmacology

authors： Moriwaki Y,Takada K,Tsuji S,Kawashima K,Misawa H

更新日期：2015-11-01 00:00:00

abstract：:Acetylcholine (ACh) acts as a local cellular signaling molecule and is widely expressed in nature, including mammalian cells and embryonic stem cells. The murine embryonic stem cell line CGR8 synthesizes and releases substantial amounts of ACh. Particularly during early differentiation - a period associated with multi...

journal_title：International immunopharmacology

authors： Michel-Schmidt R,Kirkpatrick CJ,Wessler I

更新日期：2015-11-01 00:00:00

abstract：:Previous studies demonstrated that annonaceous acetogenin (AA) was an antitumor drug with anti-angiogenic activity. However, the effect of AA on ocular neovascular disorders remains unclear. The aim of the present study is to explore the effect of AA092, an annonaceous acetogenin mimetic, on corneal neovascularization...

journal_title：International immunopharmacology

authors： Zhang J,Zhou H,Jiang S,Jin J,Li W,Wang W,Su SB

更新日期：2015-10-01 00:00:00

abstract：:Arsenic has already been demonstrated to activate the nuclear factor erythroid 2-related factor 2 (NRF2) in many different organs and cell lines. The present study tried to explore the expression of NRF2 pathway by acute arsenic exposure in immune system in vivo. Our results showed that treatment with arsenic (sodium ...

journal_title：International immunopharmacology

authors： Duan X,Li J,Zhang Y,Li W,Zhao L,Nie H,Sun G,Li B

更新日期：2015-10-01 00:00:00

abstract：:Dermonecrotic toxin (DNT) produced by Bordetella bronchiseptica (B. bronchiseptica) can cause clinical turbinate atrophy in swine and induce dermonecrotic lesions in model mice. We know that the N-terminal of DNT molecule contains the receptor-binding domain, which facilitates binding to the target cells. However, we ...

journal_title：International immunopharmacology

authors： Wang C,Liu L,Zhang Z,Yan Z,Yu C,Shao M,Jiang X,Chi S,Wei K,Zhu R

更新日期：2015-10-01 00:00:00

abstract：:Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

journal_title：International immunopharmacology

authors： Hou L,Wang T,Sun J

更新日期：2015-10-01 00:00:00

abstract：:The therapeutic effects of intravenous immunoglobulin (IVIG) products were recently studied in Alzheimer's disease (AD) patients. Pilot studies produced encouraging results but phase II and III trials gave disappointing results; a further study is in progress. IVIG products contain antibodies to tau protein, the main ...

journal_title：International immunopharmacology

authors： Loeffler DA,Klaver AC,Coffey MP

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of quercetin (Que) against perfluorooctanoic acid (PFOA)-induced liver injury in mice and its possible mechanisms of action. Mice were intragastrically administered PFOA (10mg/kg/day) alone or in combination with Que (75 mg/kg/day) for 14 consecutiv...

journal_title：International immunopharmacology

authors： Zou W,Liu W,Yang B,Wu L,Yang J,Zou T,Liu F,Xia L,Zhang D

更新日期：2015-09-01 00:00:00

abstract：:Previous studies have suggested that stearoyl lysophosphatidlycholine (LPC) protects against lethal experimental sepsis by inhibiting lipopolysaccharide (LPS)-induced extracellular release of high-mobility group box 1 (HMGB1). However, limited information exists on the mechanism by which stearoyl-LPC suppresses the ex...

journal_title：International immunopharmacology

authors： Kim JM,Han HJ,Hur YH,Quan H,Kwak SH,Choi JI,Bae HB

更新日期：2015-09-01 00:00:00